Extending the time domain of neuronal silencing with cryptophyte anion channelrhodopsins
RapACR, nicknamed so for “rapid,” an ACR from Rhodomonas salina, is reported that exhibits channel half-closing times below 10 ms and achieves equivalent inhibition at 50-fold lower light intensity in lentivirally transduced cultured mouse hippocampal neurons as the second-generation engineered Cl–-conducting channelrhodopsin iC++.
May 1, 2018
