neuronal inhibition

Extending the time domain of neuronal silencing with cryptophyte anion channelrhodopsins
RapACR, nicknamed so for “rapid,” an ACR from Rhodomonas salina, is reported that exhibits channel half-closing times below 10 ms and achieves equivalent inhibition at 50-fold lower light intensity in lentivirally transduced cultured mouse hippocampal neurons as the second-generation engineered Cl–-conducting channelrhodopsin iC++.
Elena G Govorunova, Oleg A Sineshchekov, Raheleh Hemmati, Roger Janz, Olivier Morelle, Michael Melkonian, Gane K-S Wong, John L Spudich
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